Comparison of therapeutic effects between CT-guided ~(125)I seed implantation and chemotherapy with Gemcitabine for the treatment of unresectable pancreatic carcinoma
- VernacularTitle:CT引导下~(125)I放射性粒子植入和单纯化疗治疗胰腺癌的疗效评价
- Author:
Feng ZHANG
;
Changbao ZHANG
;
Jianming TIAN
;
Jing GONG
;
Gaofeng SUN
- Publication Type:Journal Article
- Keywords:
~(125)I seed implantation;
pancreatic carcinoma;
Gemcitabine
- From:
Journal of Interventional Radiology
2009;18(9):673-676
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effects of CT-guided ~(125)I seed implantation with simple Gemcitabine chemotherapy for the treatment of unresectable pancreatic carcinoma. Methods Forty-six untreated patients with unresectable advanced pancreatic carcinoma were randomly divided into two groups: group A (n = 22), treated with ~(125)I seed implantation and group B (n = 24), treated with intravenous chemotherapy using Gemcitabine only. The clinical benefit response (CBR), objective tumor response (OTR), safety and the improvement of living quality were evaluated and analyzed. Results Three months after the treatment, the OTR rate of group A and group B was 45.5% and 8.33% respectively (P < 0.05). The CBR rate of group A and group B was 47.1% and 25% respectively (P < 0.05). No significant difference in PFS between group A and group B (P > 0.05). And also, the incidence of hematological toxicity and complication between two groups were of no significant difference. Conclusion For the treatment of advanced unresectable pancreatic carcinoma, both simple Gemcitabine chemotherapy and ~(125)I seed implantation are able to obtain a moderate objective response, although ~(125)I seed implantation seems to be more effective than Gemcitabine in improving the living quality and survival rate.
