Immunological characteristics of bone marrow-derived mesenchymal stem cell and its application in acute tubular necrosis
10.3969/j.issn.1673.8225.2009.36.037
- VernacularTitle:骨髓间充质干细胞免疫学特性研究及在急性肾小管坏死中的应用
- Author:
Nanmei LIU
;
Jinyuan ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(36):7179-7182
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow-derived mesenchymal stem cells (MSCs) have potentials of proliferation, multilineage differentiation and homing to injured tissue and organs. Therefore, many researchers consider them as seed cells and attempt to use them to repair injured tissues and organs. In the allo- even xero-transplantation of these seed cells, graft rejection is an important problem. A large amount of data show that MSCs have specific immune characteristics; they block dendritic cell maturation, decrease immune response of T cells, do not express class Ⅱ major histocompatibility complex molecules, and mediate immunosuppression by secreting some dissoluble factors. The specific low immunogenicity of MSCs could avoid rejection in xero-trensplantation for human and animals in vivo, showing advantages in treatment. Therefore, they are promising to be used as seed cells for kidney construction.
