Analysis of cervix HPV infection and its genotypes in women in Wuxi area

VernacularTitle:无锡地区妇女宫颈HPV感染及基因型别分析
Author: Jinwei ZHANG ; Jian GUO ; Zhenya LIU
Publication Type:Journal Article
Keywords: Human papillomavirus 6; Human papillomavirus 11; Human papillomavirus16; Cervix uteri; Genotype; Oligonucleotide array sequence analysis
From: International Journal of Laboratory Medicine 2009;30(9):838-840
CountryChina
Language:Chinese
Abstract: Objective To detect the genotypes of human papillomaviral infection(HPV)in 970 women who were suspicious as HPV infection, and to investigate its clinical significance. Methods Cervical cast-off cells were acquired with the special cervix brush. DNA hybridization technique was applied to detecting HPV genotypes in 970 clinical specimens. Results Totally 390 case(40.2%) were HPV positive among 970 clinical specimens. A total of 12 subtypes were detected. In 390 cases of HPV infection,260 cases (26.8%) were infected with single HPV subtype, and while 130 cases(13.4%) were with infection of two or above HPV subtypes. HPV6 and 11 were the most frequent low-risk sub-types,and in the high-risk subtypes,HPV16,33,52,58 and 18 were dominant. Conclusion The cervix HPV infection rate is considerable in women in Wuxi area. HPV6 and 11 are the most frequent sub-types. The determination of HPV genotypes plays all important role in early discovery, prevention and treatment of gential tract and cervical cancer.