Correlation study on serum levels of slCAM-1 and hs-CRP in newborn infants with hypoxic-ischemie eneephalopathy
10.3760/cma.j.issn.1673-4130.2009.09.004
- VernacularTitle:新生儿缺氧缺血性脑病患者血清可溶性细胞间黏附分子-1与超敏C反应蛋白浓度相关性研究
- Author:
Fan YUAN
;
Yunyan PAN
- Publication Type:Journal Article
- Keywords:
Cell adhesion molecules;
C-reactive protein;
Hypoxia-ischemia;
brain;
Infant;
newborn
- From:
International Journal of Laboratory Medicine
2009;30(9):841-842
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum levels of soluble intercellular adhe-sion molecule-1(slCAM-1) and high-sensitivity C reactive protein (hs-CRP) in newborn infants with hypoxic-ischemie encephalopathy(HIE),as well as the clinical significance of the above two indicators in evaluating prognosis and pathogenetic condition, Methods Immunoturbidimetry(ITM) was applied to measuring hs-CRP,and enzyme linked immunosorbent assay(ELISA) was used to detect slCAM-1. Results As compared with those of healthy control group,the serum levels of hs-CRP and slCAM-1 were significantly increased in acute phase group(P<0.01). However, the serum levels of hs-CRP and sICAM-1 were declined in recovery phase group. No statistical difference was found between recovery phase group and healthy control group(P>0.05). Conclusion Serum slCAM-1 and hs-CRP may be used as useful indicators of prognosis and pathogenetic condition.