Clinical significance of combined measurement of PreS1 antigen and HBV serological markers in patients with hepatitis B
10.3760/cma.j.issn.1673-4130.2009.09.010
- VernacularTitle:乙肝患者血清前S1抗原和乙肝血清标志物联合检测的意义
- Author:
Chunhong YAO
;
Jianping DENG
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Biological markers;
Clinical laboratory techniques
- From:
International Journal of Laboratory Medicine
2009;30(9):854-855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between PreS1 antigen and five items of HBV serological markers(HBV M), as well as the clinical significance of combined measurement of PreS1 antigen and HBV M in patients with hepatitis B. Methods Enzyme linked immunosorbent assay (ELISA) was applied to testing serum in 268 patients with hepatitis B. Results The detection rate of PreS1 antigen was 85.88% in HBeAg'positive samples,significantly higher than that in HBeAg nega-tive samples(39.34%), P<0.01. Conclusion PreS1 antigen may effectively reflect the situation of HBV amplification. Combined measurement of PreS1 antigen and HBV serological markers in clinical examination contributes to clinical diagnosis,therapeutic effect monitoring and prognosis evaluation.
