Effect of large dose of magnesium sulfate on patients with brain injury
- VernacularTitle:大剂量硫酸镁对脑外伤治疗作用的研究
- Author:
Guosheng ZHOU
;
Hongyang ZHAO
;
Xianli ZHU
- Publication Type:Journal Article
- From:
Chinese Journal of Trauma
2001;17(3):161-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of large dose of magnesium sulfate used to treat patients with brain trauma. Methods According to standards 32 patients were chosen and divided into experimental group and control group at random. Sixteen patients in experimental group received 16 mmol magnesium sulfate intravenously over 15 minutes, followed by 65 mmol over 24 hours; while 16 patients in control group received nothing. Serum NSE, GCS and GOS of all the patients were measured after 3 days, 2 weeks and 6 months, respectively and the data were analyzed statistically. Results The serum NSE, GCS and GOS in experimental group were (24.8±19.2) μg/L, 12.3±3.3 and 3.6±1.4, respectively; while the serum NSE, GCS and GOS in control group were (49.7±23.1) μg/L, 9.8±2.8 and 3.1±1.6, respectively. Between the two groups the serum NSE and GCS were different significantly (P<0.01, P<0.05, respectively) while the GOS was not (P>0.05). Conclusions Large dose of magnesium sulfate is effective to treat patients with brain injury at least within a short term.
