Drug delivery of CPC/cisplatin complex in vitro and its ability to repair bone defect and eliminate tumor in vivo
- VernacularTitle:磷酸钙骨水泥/顺铂复合体体外药物缓释及体内抑瘤和修复骨缺损的实验研究
- Author:
Yanning LIU
;
Miao LIU
;
Pengyu REN
- Publication Type:Journal Article
- Keywords:
calcium phosphate cement;
cisplatin;
osteosarcoma cell;
bone defect;
drug delivery
- From:
Journal of Central South University(Medical Sciences)
2009;34(10):991-997
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best mass ratio of calcium phosphate cement (CPC) / cisplatin complex filling and to repair bone defect caused by tumor resection. Methods Mixed-molding method was used to obtain cisplatin/calcium phosphate cement complex at 0, 0.1%, 0.2%, and 0.4% mass ratio. Drug concentration was determined by atomic absorption spectrophotometry. Bone defect of rabbits and osteosarcoma of rats were prepared. We implanted CPC and CPC/cisplatin complex to observe the repair of bone defect and the inhibition of tumor in vivo. Results CPC containing 0.1% ～ 0. 2 % cisplatin not only repaired the bone defect in rabbits but also eliminated osteosarcoma in rats. Conclusion CPC containing 0.1% ～ 0. 2 % cisplatin can repair bone defect and eliminate tumor without influencing the prosthetic precess.
