Prostaglandin E_2 and omeprazole in treating poisoning related acute mucosal lesion
- VernacularTitle:前列腺素和奥美拉唑联合治疗有机磷中毒性胃黏膜损伤的疗效
- Author:
Xiao FAN
;
Yang XU
;
Hongliang ZHANG
- Publication Type:Journal Article
- Keywords:
prostaglandin;
omeprazole;
endothelin;
tumor necrosis factor-α;
organophosphate poisoning
- From:
Journal of Central South University(Medical Sciences)
2009;34(10):1036-1041
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of prostaglandin E_2 alone and the combination with omeprazole for poisoning related acute mucosal lesion. Methods Forty-two healthy SD rats were randomly divided into 7 groups: control group (control), methamidophos poisoning model group (intox), 10 mg/kg omeprazole group (ome1), 50 mg/kg omeprazole group (ome2), 10 μg/kg prostaglandin E_2 group (PG1), 50 μg/kg prostaglandin E_2 group (PG2), 10 μg/kg prostaglandin E_2 combined with 10 mg/ kg omeprazole group (union). The gastric ulcer index was counted and the content of serum cholinesterase, endothelin, and tumor necrosis factor were measured, and dependability was analyzed. Results There was no obvious difference between the prostaglandin group and the poisoning model group in gastric ulcer index, endothelin, and tumor necrosis factor. The omeprazole alone and the combination treatment could improve the acute gastric mucosa lesion induced by methamidophos poisoning. Conclusion Prostaglandin E_2 alone can not obviously improve the acute gastric mucosa lesion by methamidophos poisoning. The combination with omeprazole may be a promising treatment.
