Association of estrogen receptor gene XbaI and PvuⅡ polymorphisms with aggressive periodontitis
10.3969/j.issn.1001-3733.2009.06.28
- VernacularTitle:雌激素受体XbaI和PvuⅡ基因多态性与侵袭性牙周炎的相关研究
- Author:
Xueli WU
;
Meilin ZHAO
;
Ping HUANG
;
Haijuan HOU
;
Guifen CAO
- Publication Type:Journal Article
- Keywords:
Aggressive periodontitis;
Estrogen receptor(ER);
Gene polymorphisms
- From:
Journal of Practical Stomatology
2009;25(6):885-888
- CountryChina
- Language:Chinese
-
Abstract:
Objective; To study estrogen receptor gene Xbal and Pvu Ⅱ polymorphisms in patients with aggressive periodontitis (AgP). Methods; Xbal and Pvu Ⅱ DNA was extracted by Chelex-100 and amplified by PCR from buccal swabs of 48 cases of AgP patients and 60 normal controls. The PCR products were analyzed by polymerase chain reaction linked fragment length polymorphism (PCR-RFLP) assay. Results: There were significant differences of the distribution of Xba I genotype between AgP group and control group, female AgP group and female control group, male AgP group and male control group(P<0.05). There was no difference of Pvu D genotype distribution between patient group and control group (P>0.05). Multivariate Logistic Regression Analysis showed that male group was less susceptible to AgP than female group(OR =0. 352), the older was less susceptible to AgP than the younger(OR =0.950), and the xxXx genotype was less susceptible to AgP than XX genotype [OR(Xx) =0.224, OR(xx) = 0.678). Conclusion: Specific relationship is found between the susceptibility of AgP and the ER gene-Xbal polymorphism. People with XX genotype is more susceptive to AgP than xx, Xx genotypes.
