Clinical Analysis of 116 Cases of Keloids Treated by Combination of Surgical Resection and Immediate Postoperative Electron Beam Radiotherapy
10.3870/J.issn.1672-0741.2009.05.027
- VernacularTitle:116例瘢痕疙瘩术后即时电子线放射治疗的临床分析
- Author:
Mengxian ZHANG
;
Na HAN
;
Shiying YU
- Publication Type:Journal Article
- Keywords:
keloid;
electron beam;
radiotherapy
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2009;38(5):683-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of postoperative electron beam radiotherapy in the management of ke-loids. Methods Between January 2004 and December 2006,116 cases of keloids were treated with 6 MeV electron beam radiotherapy within 24 h after surgical resection of the keloids. All patients had received a total of 21 Gy in seven daily 3-Gy fractions. Treatment was started at the 24th h after surgery. Patients were followed up and the information regarding treatment results, early and late radiation toxicity,and the satisfaction level by self-assessments was recorded. Results Recurrence occurred in 17 cases of keloids(14. 7%),and was correlated with site of the lesions(χ~2 =29. 91,P<0. 01). Most recurrences were observed at site of sternum (10/43) and shoulder (5/13 ). Keloid associated symptoms, e. g. itching and pain, were improved in 88. %%. For early toxicity outcomes, 100% had grade 1～2 skin erythema,7. 8% had wound delayed union,and 4. 3% had infection. For late toxicity outcomes, 30. 2% reported grade 1～2 hyperpigmentation, 11. 2% grade 1～2 hypopigmentation, and 5. 2% grade 1 telangiectasia. No severe complications or secondary malignancies were observed. 72. 4% patients described the results of treatment as excellent or good,and 15. 5% patients were not satisfied with the treatment results. Conclusion Postoperative electron radiotherapy is well tolerated and effective in preventing keloid recurrence.
