Expression and significance of PCS, PC7, VEGF-C, VEGF-D and VEGFR-3 mRNA in non-small cell lung cancer
- VernacularTitle:PC5、PC7、VEGF-C、D及其受体VEGFR-3 mRNA在非小细胞肺癌淋巴转移中的表达及意义
- Author:
Chao CHANG
;
Ping WANG
;
Libin ZHANG
- Publication Type:Journal Article
- Keywords:
proprotein convertase 5,7;
vascular endothelial growth factor-C,D;
vascular endothelial growth factor receptor-3;
non-small cell lung cancer;
lymphatic metastasis
- From:
China Oncology
2009;19(10):742-748
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: Infiltration and metastasis are characteristic of the biological behavior of cancer. Blood circulation and lymphatic spread are two important ways for neoplasm metastasis. The lymphatic vessel is one of the earliest routes for solid neoplasm metastasis. However, compared to tumor blood vessels, there were only a few studies on the research for lymphatic vessel spread. In recent years, with the identification of vascular endothelial growth factor-C (VEGF-C), VEGF-D and lymphatic endothelial markers including lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3), glomerular podocyte membrance mucoprotein (podoplanin) and the homeobox transcription factor (Prox-1), lymphangiogenesis has become one of the important areas in the study of tumor metastasis. This paper was to study the expression of proprotein convertase (PC)5, PC7, VEGF-C, VEGF-D and their receptor VEGFR-3 in patients with non-small cell lung cancer (NSCLC) and their clinico-pathoiogical value. Methods: Twenty specimens of the NSCLC, peritumoral tissues as experimental group and nine pulmonary benign diseases as control group were studied. The expression of PC5, PC7, VEGF-C, VEGF-D and VEGFR-3 mRNA in specimens of those tissues were studied by real-time quantitative reverse transcriptase polymerase chain reaction (real-time quantitative RT-PCR). Results: ①The expressions of PC5, PC7, VEGF-C, VEGF-D, VEGFR-3 mRNA in specimens of NSCLC were significantly higher than those of the peritumoral and pulmonary benign diseases tissues (P
