Progress on the thyroid hormone receptor gene mutation and its downstream pathways associated with tumor
- VernacularTitle:甲状腺激素受体(TR)基因突变及其下游通路与肿瘤相关研究进展
- Author:
Wei SANG
;
Jin ZHAO
- Publication Type:Journal Article
- Keywords:
thyroid hormone;
thyroid hormone receptor;
receptor mutation;
β-catenin
- From:
China Oncology
2009;19(10):802-806
- CountryChina
- Language:Chinese
-
Abstract:
Signaling pathways such as MAPK and P13K have been confirmed to be important in the mechanism of tumor genesis, development, prevention and treatment. Thyroid hormone (TH) and its receptor (TR) can affect the pathways resulting in inhibition of tumor growth and metastasis, thus they have gradually become the focus of recent research. However, numerous studies showed that TR gene mutation was often observed in a variety of cancers and resulted in the deregulation of TH/TR mediated downstream pathways, and TR gene mutation became an causative agent to activate downstream proto-oncogene. Recent studies showed that TH/TR might play a role in the regulation of β-catenin degradation, the knowledge of which allows us not only to further understand the function of TR gene in the inhibition of tumor development, but also provide a theoretical basis for the continuous activation of downstream proto-oncogene by TR mutation. To study the downstream pathway of TR gene could eventually guide the clinician and provide a new theoretical basis for cancer prevention and molecular target gene therapy.
