The expression of type Ⅱ collagen in articular chondrocyte of osteoarthritis
- VernacularTitle:Ⅱ型胶原在骨关节炎软骨细胞中的表达
- Author:
Chunhui MA
;
Guoping CAI
;
Zuoqin YAN
;
Changan GUO
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
type Ⅱcollagen;
reverse transcriptase polymerase chain reaction;
articular chondrocyte
- From:
Fudan University Journal of Medical Sciences
2009;36(6):734-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of type Ⅱ collagen in the articular chondrocyte of osteoarthritis (OA) patients and normal human. Methods The samples of articular cartilage were obtained from the patients undergoing total joint replacement, including 8 primary OA patients, 8 secondary OA patients and 9 normal subjects. Type Ⅱ collagen expression in chondrocyte was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Results The expressin of type Ⅱ collagen mRNA in normal OA group was higher than that in primary OA group and secondary OA group with a statistical difference (P=0.014), while there was no statistical difference between primary OA group and secondary OA group(P=0.716). Conclusions The reduction of type Ⅱ collagen expression leads to the change of collagen directly and possibly plays an important role in OA, which is the common pathway of the occurrence of both the primary and secondary OA.
