The expression and clinical significance of FGFR2, and c-Cbl in gastric carcinoma
- VernacularTitle:FGFR2和C-Cbl在胃癌组织中的表达及其临床意义
- Author:
Linlin LI
;
Yunpeng LIU
;
Kezuo HOU
;
Xiujuan QU
;
Oiang LI
;
Oian DONG
;
Na SONG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
tissue microarray;
FGFR2;
c-Cbl
- From:
China Oncology
2009;19(8):609-614
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: FGFR2 is a receptor tyrosine kinase and c-Cbl is a new RING finger type of ubiquitin ligase in the ubiquitin-proteasomes path. The purpose of this study was to evaluate the expression and significance of FGFR2 and c-Cbl in gastric carcinoma. Methods: The expression of FGFR2 and c-Cbl were detected by immunohistochemical method of SP. Results: The positive expression rates of FGFR2 and c-Cbl were 77.4%,71.0% in gastric carcinoma, respectively, both were higher than those normal tissue (P<0.05);The expression of FGFR2 and c-Cbl were positively correlated with depth of invasion and TNM staging, and there was a positive relationship between the expressions of FGFR2 and c-Cbl. Conclusion. The expressions of FGFR2 and c-Cbi were associated with some clinicopathologic features in gastric carcinoma, indicating that their expression may be the prognostic factors for gastric carcinoma.
