The effects of orthodontic force on the expression of IL-6 and the alveolar bone remodeling in rats

VernacularTitle:正畸力作用下大鼠白细胞介素-6的表达及牙槽骨改建的研究
Author: Yajing QIAN ; Liangjun ZHONG ; Xiaobing LI ; Jing NIE ; Baoshan LIN ; Lin ZAN
Publication Type:Journal Article
Keywords: Orthodontic tooth movement; Interleukin-6; Alveolar bone remodeling; SD Rats
From: Journal of Practical Stomatology 2009;25(6):783-786
CountryChina
Language:Chinese
Abstract: Objective; To investigate the expression and distribution of IL-6 in periodontal tissues and the change of the alveolar bone of rats during orthodontic tooth movement, and to study the effects of orthodontic force on the periodontal tissue remodeling. Methods: SO gram orthodontic force was loaded on the left first maxillary molars of 25 rats in experimental group. Immunohistochem-istry and histomorphometric analysis were performed to measure the expression of IL-6 and the loss of alveolar bone at 0, 1, 3, 5, 7 " and 10 days after the application of orthodontic force. Results; The expression of IL-6 was observed to reach maximum level on day 3 and to decline thereafter in experimental group. No obvious alveolar bone loss was detected in the mesial side of the first molars. Conclusion; Although orthodontic force can evoke the local inflammatory response of periodontal tissue and the expression of pro-inflammation cytokines such as IL-6, it can not cause severe periodontal destruction and alveolar bone loss.