The expressions of HIF-1α and RTP801 mRNA in oral lichen planus
10.3969/j.issn.1001-3733.2009.06.20
- VernacularTitle:缺氧诱导因子-1α和RTP801 mRNA在口腔扁平苔藓组织中的表达及意义
- Author:
Yuan FAN
;
Juanyong XU
;
Jiong BAO
- Publication Type:Journal Article
- Keywords:
Hypoxia- inducible factor-1α;
RTPS01;
Mouth;
Lichen planus
- From:
Journal of Practical Stomatology
2009;25(6):850-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the pathogenesis of oral lichen planus (OLP) by examining the expressions of hypoxia-inducible factor-la and RTP801 in OLP. Methods: To determine the expression levels of HIF-la and RTP801 in 24 OLP tissues and 12 normal oral mucosa tissues by real-time fluorescence quantitative PCR. Results; The expression of HIF-1α in OLP was higher than that in normal oral mucosa(P <0.05), while the expression of RTP801 in OLP was lower than that in normal oral mucosa( P <0.05). Conclusion; The abnormal expressions of HIF-la and RTP801 may play an important role in the pathogenesis of oral lichen planus. HIF-1α might be a potential molecular target for the treatment of OLP.
