The correlation between interleukin-4,15 as well as 18 and telomerase activity in myasthenia gravis
- VernacularTitle:重症肌无力中白介素4、15、18与端粒酶活性的相关性研究
- Author:
Min CHEN
;
Xuean MO
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis(MG);
IL-4;
IL-15;
IL-18;
Telomerase
- From:
Chinese Journal of Immunology
2009;25(11):1006-1008
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the serum levels of IL-4,IL-15 and IL-18 in myasthenia gravis( MG) and investigate the correlations between telomerase activity of CD4~+ T lymphocytes and these interleukins.Methods:The serum levels of IL-4,IL-15 and IL-18 were detected with ELISA and telomerase activity was detected by polymerase chain reaction enzyme-linked immonosorbent assay(PCR-ELISA) in 30 MG patients and 30 negative controls.Results:The levels of IL-4,IL-15,IL-18 and telomerase of CD4~+ T lymphocytes in MG were significantly higher than those in negative controls (P<0.01).There were positive correlations between the serum levels of IL-4,IL-15,IL-18 and telomerase activity of CD4~+ T cell in MG patients (P<0.01).Conclusion:IL-4,IL-15,IL-18 and telomerase activity of CD4~+ T lymphocytes are involved in the pathogenesis of MG;IL-4,IL-15 and IL-18 may upregulate the telomerase activity of CD4~+ T cells.
