The relation between platelet activation and hypercoagulability in elderly patients with chronic cor pulmonary exacerbation
- VernacularTitle:血小板活性与老年慢性肺心病高凝状态的关系
- Author:
Weiming WU
;
Jie TAN
;
Yongyi GUO
;
Jin HUANG
- Publication Type:Journal Article
- Keywords:
Chronic cor pulmonale;
Activated platelet;
Flow cytometry;
Fibrinogen;
D-dimer
- From:
Chinese Journal of Immunology
2009;25(11):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relation among platelet activation marker(GPⅡb/Ⅲa,CD62p) and amounts of fibrinogen (FG) and of D-dimer (DD) in elderly patients with chronic cor pulmonale exacerbation.Methods:Subjects were divided into four groups (42 elderly patients with chronic cor pulmonale exacerbation,42 elderly patients with chronic cor pulmonale remission stage,30cases of healthy elderly controls and 30 cases of healthy non-elderly controls).Positive rates of GPⅡb/Ⅲa and CD62p were measured with tricolor flow cytometry.We also determined FG and DD in patients with chronic cor pulmonale and in normal controls.Results:Compared with those of chronic cor pulmonale remission stage group,healthy elderly group and healthy non-elderly group,the levels of GPⅡb/Ⅲa,CD62p,FG and DD increased significantly in elderly patients with chronic cor pulmonale exacerbation (all P<0.001).There was a positive correlation between the amount of GPⅡb/Ⅲa or CD62p and the amount of FG and DD in elderly patients with chronic cor pulmonale exacerbation.Conclusion:There is increased coagulation and platelet activity in elderly patients with chronic cor pulmonale exacerbation,and there is a significant correlation between platelet activity and hypercoagulability.
