Influences of anxiety on humoral immune functions and the correlations with HLA-DQB1
- VernacularTitle:焦虑对体液免疫功能影响及其与HLA-DQB1等位基因的关系
- Author:
Kun GAO
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
Anxiety;
Humoral immune function;
HLA-DQB1
- From:
Chinese Journal of Immunology
2009;25(11):1045-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between anxiety and the change of humoral immune functions and its correlation with HLA-DQB1 polymorphisms.Methods:Total 31 resident doctors were selected randomly and tested by State-Trait Anxiety Inventory(STAI).IgG,IgA,IgM,complement C3 and complement C4 were detected with BECKMAN array360 system;HLA-DQB1*02、*03、*04、*05 and*06 alleles were individually amplified by polymerase chain reaction(PCR)using exon2 group-specific primers.The correlation between immune function and HLA-DQB1 polgmorphisms were investigated.Results:Statistical analysis showed that there was positive correlation with State Anxiety (Ta) and complement C3,either Trait Anxiety (Tc) and complement C3.There was significant difference between HLA-DQB1*02 positive and negative in Ta (P＜0.05),while no difference in complement C3(P＞0.05).There was significant difference between HLA-DQB1*04 positive and negative in Ta and Tc(P＜0.05),while no difference in complement C3(P＞0.05).Conclusion:Anxiety could change some humoral immune functions and this is related with HLA-DQB1 polymorphism.
