The levels of serum tHcy and Lp(a) and their relation with insulin resistance in patients with combined type 2 diabetes and CHD

VernacularTitle:2型糖尿病合并冠心病患者血同型半胱氨酸、脂蛋白a水平及其与胰岛素抵抗相关性
Author: Caiping ZHOU ; Yaqin ZHOU
Publication Type:Journal Article
Keywords: Homocysteine; Lipoprotein(a); Diabetes mellitus; type 2; Coronary heart disease; Insulin resistance
From: Chinese Journal of Diabetes 2009;17(11):804-805
CountryChina
Language:Chinese
Abstract: Objective To investigate the levels of serum tHcy and Lp(a)and their association with insulin resistance in patients with type 2 diabetes and CHD. Methods T2DM patients were divided into two groups with CHD and without CHD in addition to normal control.The fasting serum levels of tHcy,Lp(a),FPG and FIns were detected, ISI were calculated，and the correlations among them were analyzed. Results The serum levels of tHcy,Lp(a),FIns,FPG of T2DM plus CHD were significantly higher than those of T2DM without CHD and controls(P<0.01~0.05).ISI was significantly lower in T2DM cases with CHD than those of T2DM cases without CHD and controls(P<0.01). ISI was negatively correlated with tHcy and Lp(a)in T2DM plus CHD group(P<0.05)but not correlated with those in T2DM case without CHD group(P>0.05). Conclusions Detections of the serum levels of tHcy and Lp(a)of T2DM play significant roles in knowing patient condition,guiding clinical treatment and earlier preventing and treating vascular complication of diabetes.