Study of correlation of diabetic nephropathy with serum endothelin(ET-1) and C-reactive protein(CRP)
10.3969/j.issn.1006-6187.2009.11.014
- VernacularTitle:糖尿病肾病与血浆内皮素1及C反应蛋白的相关性研究
- Author:
Wen HUANG
;
Weihua FENG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Endothelin-1;
C-reactive protein
- From:
Chinese Journal of Diabetes
2009;17(11):842-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of diabetic nephropathy with serum endothelin-1(ET-1) and C-reactive protein(CRP). Methods Levels of blood pressure, glucose, lipid, creatinine,ET-1,CRP and urinary albumin excretion(UAER) were measured and calculated in 86 patients with type 2 diabetes mellitus(T2DM)and 30 healthy subjects. Results Serum ET-1 and CRP were significantly higher in T2DM than in control(P<0.05，P<0.01).Serum ET-1 and CRP were increased with increment of serum creatinine and UAER(P<0.05，P<0.01). Conclusions Serum ET-1 and CRP may be involved in the development and progression of diabetic nephropathy.
