Experimental study on the protection against podocyte injury by simvastatin in diabetes mellitus rats
10.3969/j.issn.1006-6187.2009.11.020
- VernacularTitle:辛伐他汀对糖尿病大鼠足细胞损伤保护作用的实验研究
- Author:
Shujun CHEN
;
Haiping CHEN
;
Qi LIU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Podocytes;
Simvastatin
- From:
Chinese Journal of Diabetes
2009;17(11):861-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protection against podocyte injury by simvastatin in DM rats. Methods We divided DM rats induced by STZ into 3 groups of NC,DM and SVT,measured Scr,TC and UAER，observed renal pathomorphology and FPW，and detected nephrin,podocin,NF-κB and MCP-1 by immunohistochemistry stain,real time-PCR. Results The levels of Scr,UAER,NF-κB and MCP-1 were higher in DM than in NC and SVT group.The level of FPW was higher in DM than in SVT group.The levels of nephrin and podocin were lower in DM than in NC and SVT group (all P<0.01). Conclusions Simvastatin can suppress inflammatory cytokines,maintain podocyte protein,relieve podocyte injury.
