Influence of oxidative stress on p53 post-translational modifications
- VernacularTitle:氧化应激对p53翻译后修饰影响的研究进展
- Author:
Zujun SUN
;
Jing YI
;
Yumei WANG
- Publication Type:Journal Article
- Keywords:
oxidative stress;
p53;
post-translational modification
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2009;29(11):1377-1382
- CountryChina
- Language:Chinese
-
Abstract:
Protein post-translational modifications are important ways to regulate protein function and cell behavior, and oxidative stress directly influences protein post-translational modifications. P53 protein has various post-translational modifications, which can be quickly regulated under stress conditions to activate a series of downstream target genes and facilitate the p53 function diversity. The effects of oxidative stress on p53 post-translational modifications of phosphorylation, ubiquitination, sumoylation, acetylation and methylation are introduced in this paper.
