Effect of NF - κB inhibitor on renal expression of apolipoprotein M in rats with acute renal failure
- VernacularTitle:载脂蛋白M在急性肾衰大鼠肾组织中的表达及NF-κB抑制剂的干预作用
- Author:
Hua TANG
;
Zhuhua LI
;
Ping ZOU
;
Na LUO
;
Chunmei ZHANG
- Publication Type:Journal Article
- Keywords:
Renal failure,acute;
Reperfusion;
Apolipoproteins M;
NF-kappa B
- From:
Chinese Journal of Pathophysiology
2009;25(11):2141-2144
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression pattern of apolipoprotein M (apoM) protein in renal cortex of a-cute renal failure ( ARF) rats with reperfusion. METHODS: Seventy - five male rats were randomly divided into sham operation group (re =25) , ARF group (n =25) and pyrrolidine dithiocarbamat (PDTC) group (n =25) , five subgroups at time points of 3 h, 6 h, 12 h, 24 h and 48 h after reperfusion were set up in each group. The expressions of apoM in cytoplasm and NF - κB p65 in nucleus of renal cortex were detected at the indicated time points. RESULTS: The expression of apoM in ARF group was obviously higher than that in sham operation group ( P <0.01 ) , and two peaks were detected, the first peak was at 6 h after reperfusion, while the second one was from 24 h to 48 h. The tendency of apoM expression in PDTC group was similar to that in ARF group, while the expression in every subgroup was prevalently lower than that in ARF group (P < 0.01). Otherwise, a significant correlation ( r = 0.852, P < 0.01) was found between the expression of apoM and NF -κB p65.CONCLUSION: The results indicate that apoM feasibly take part in the pathogenesis of ARF through the inflammatory reaction mediated by NF - κB.
