Effects of glucocorticoid inhalation on the levels of CD4~+CD25~+ regulatory T cells in peripheral blood of asthmatic children
- VernacularTitle:糖皮质激素吸入对哮喘患儿外周血CD4~+CD25~+调节性T细胞水平的影响
- Author:
Huarong HUANG
;
Tiantian LIU
;
Jing WEI
;
Weiping TAN
;
Baojing WU
;
Xiandi MAI
- Publication Type:Journal Article
- Keywords:
CD4~+CD25~+ regulatory T cells;
Asthma;
Glucocorticoids;
Inhalation therapy;
Child
- From:
Chinese Journal of Pathophysiology
2009;25(11):2204-2207
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of glucocorticoid inhalation on the levels of CD4~+CD25~+ regulatory T cells in peripheral blood of asthmatic children. METHODS: Glucocorticoid inhalator was inhaled by 70 children with attack asthma. The levels of CD4~+CD25~+ Tr in peripheral blood of asthmatic children were tested by flow cytometry (FCM). RESULTS: The CD4~+CD25~+ Tr levels in peripheral blood of asthmatic children were (5.62% ± 1.29% ) and (7.05% ± 1.61%) before and after of regulated glucocorticoid inhalation, respectively (P<0.01). The Tr levels were (7.56% ± 1.88% ) , (7.09% ± 1.23% ) and (6.11% ± 1.96% ) in the complete control group, part control group and poor control group, respectively ( P < 0.05 ). The Tr level in formal treatment group (7.05% ±1.61%) was higher than that in irregular treatment group ( 5.91 % ± 1.76% ), P < 0.01.CONCLUSION: The level of CD4~+CD25~+ Tr is remarkable increased by regulated glucocorticoid inhalation, and the level of Tr can reflect the effects of glucocorticoid inhalation.
