Role of microRNA in hematological malignancies
- VernacularTitle:MicroRNA与血液系统肿瘤发生、诊断和治疗
- Author:
Yumin LI
;
Jia FEI
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Hematologic neoplasms
- From:
Chinese Journal of Pathophysiology
2009;25(11):2225-2229
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA ( miRNA) is a family of 19 - 24 nucleotides small non - coding RNA in eukaryotic organisms , which can regulate genes at the post - transcriptional level. miRNA has been shown to be involved in a variety of cellular processes such as development, proliferation, differentiation, apoptosis etc, and is closely related to the oncogene-sis. Recent study indicates that several miRNAs play an important role in initiation and progression of hematological malignancies. miRNA expression profiling has identified signatures associated with diagnoses, prognoses and therapy of hematological malignancies. The review discusses miRNA and its biogenesis, functional mechanisms and potential role in the diagnosis , prognoses and therapy of hematological malignancies.
