The Expression of c-erbB-2, p53, PCNA and bcl-2 in Breast Cancer and Its Clinical Significance
10.3969/j.issn.1000-8179.2009.21.010
- VernacularTitle:乳腺癌组织中c-erbB-2 p53 PCNA及bcl-2蛋白的表达及其临床意义
- Author:
Haibo LU
;
Dongliang WANG
;
Qingyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Immunohistochemistry;
Oncogene;
Gene expression
- From:
Chinese Journal of Clinical Oncology
2009;36(21):1232-1234
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the correlation of the expression of c-erbB-2, p53, PCNA and bcl-2 with the biological behavior of breast cancer. Methods: We used immunohistochemistry to detect the expression of c-erbB-2, p53, PCNA and bcl-2 in 56 breast cancer patients. Results: The expression of c-erbB-2 was 41.1% and was negatively correlated with histological classification but was not correlated with age, clinical stage, ER, or PR. The expression of p53 was 48.2% and was positively related with ER and PR but was negatively correlated with clinical stage and pathological type. The expression of bcl-2 was 50.0% and was negatively correlated with histological classification, ER and PR and was positively correlated with clinical stage and pathological type. PCNA was highly expressed in the 56 cases. Conclusion: We should combine the detection of c-erbB-2, p53, PCNA and bcl-2 with the evaluation of clinical stage, histological degree and pathological type in order to improve the prognostic estimation of breast cancer.
