Application of macromolecular compound and drug biological barrier in preventing tendon adhesion
10.3969/j.issn.1673-8225.2009.38.036
- VernacularTitle:高分子化合物及药物薄膜屏障在预防肌腱损伤中的应用
- Author:
Jing LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(38):7563-7566
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE: To explore the mechanisms of chitosan, absorbable membrane, and hyaluric acid in preventing adhesion following tendon injury. METHODS: The Chinese Journal Full-text Database, as well as Pubmed database, were retrieved with key words of tendon adhesion, high polymer biological barrier, several Ding keeps out, absorbability antiseize continually membrane, and hyaluric acid. The quality, as well as inflammatory reaction surrounding tensions were served as evaluate indexes, accordingly, the English and Chinese papers regarding mechanisms of chitosan, absorbable membrane, and hyaluric acid in preventing tendon adhesion were included. Studies concerning other biomaterials were excluded. RESULTS: A total of 223 papers were obtained by initial search with computer. According to inclusion criteria, the related papers were analyzed. Adhesion formation associated with tendon surgery is a widespread problem. Tendon healing was classically considered to occur through extrinsic and intrinsic healing, in which the extrinsic healing was closely associated with the formation of adhesion or scar, so if we can accelerate proliferation of granulation tissue, inhibit the extrinsic healing of the tendon, the purpose of preventing tendon adhesion formation could be achieved. As a result, macromolecular compound and drug biology barrier were widely used. CONCLUSION: High polymer biological barrier can relieve tendon adhesion by its barrier function and pharmacologic action to regulate healing mechanisms.
