Chiral Separation of Naphthylglycidic Ether Using Capillary Zone Electrophoresis
- VernacularTitle:α-萘基缩水甘油醚对映体的毛细管区带电泳手性拆分
- Author:
Rong XIAO
;
Dan ZHANG
;
Peigang DU
;
Yueying LUO
;
Xin ZHAO
;
Yan LIU
;
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
Naphthylglycidic ether;
chiral separation;
capillary electrophoresis;
cyclodextrins
- From:
Chinese Journal of Analytical Chemistry
2009;37(11):1695-1699
- CountryChina
- Language:Chinese
-
Abstract:
A capillary electrophoretic method was developed for the separation of enantiomers of naphthylgly-cidic ether(NGE). Several cyclodextrins(CDs) were applied as the chiral selectors and it was found that the ionic modified highly sulfated cyclodextrin(HS-β-CD) could give satisfactory enantioselectivity. In addition,the effects of the pH value of the buffer system,the concentration of the HS-β-CD,capillary temperature and the running voltage on the chiral separation were investigated systematically. The result showed that under the optimized conditions of pH 2. 5,20 mmol/L H_3PO_4-triethanolamine buffer containing 2% highly sulfated cyclodextrin ( HS-β-CD) at capillary temperature 20℃ in the reversed polarity voltage of - 18 kV,the enantiomers of naphthylglycidic ether were baseline separated. This method is simple,precise and can be applied to the chiral separation of naphthylglycidic ether enantiomers and determination of enantiomers excess(ee,% ).
