Effects of pyrroloquinoline quinone on proliferation and expression of NF-κB in cultured Schwann cells
- VernacularTitle:吡咯喹啉醌对雪旺细胞增殖及NF-κB表达的影响
- Author:
Bin HE
;
Shiqing LIU
;
Haohuan LI
- Publication Type:Journal Article
- Keywords:
pyrroloquinoline quinone;
Schwann cell;
proliferation;
NF-κB
- From:
Orthopedic Journal of China
2009;17(21):1647-1650
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effects of pyrroloquinoline quinine (PQQ) on proliferation and expression of NF - kB of Schwann cells. [Methods] Schwann cells were cultured from sciatic nerves of SD rats in vitro. The Schwann cells were identified and purified by immunofluorescence of S-100 and Ara-C. Experimental group with was 100 nmol/L of PQQ and control group were set up. The expression of NF-kB in Schwann cells was determined by RT-PCR and Western blotting. [ Results] The expression of NF - kB were up - ragulated by PQQ in cultured Schwann cells (P<0.05).[Conclusion ] PQQ could promote the proliferation of Schwann cells and up-regulation of NF-rd3 play an important role in this process.
