Correlation with ketamine concentration in plasma and saliva in rabbits
- VernacularTitle:家兔唾液与血液中氯胺酮浓度的相关性
- Author:
Pengwang LI
;
Junfang LIU
;
Yujin WANG
- Publication Type:Journal Article
- Keywords:
forensic toxicology;
ketamine;
norketamine;
saliva;
plasma;
correlation
- From:
Chinese Journal of Forensic Medicine
2009;24(6):389-391
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation with ketamine and its metabolite norketamine concentration in plasma and saliva in acute toxic rabbits.Methods Experimental rabbits were given intragastric(i.g.group,n=6)and intravenous(i.v.group,n=6)administration of ketamine respectively,and control tabbits(n=6)were given a same volume of physiologic saline.The plasma and saliva were collected before and after ketamine administration.Ketamine and norketamine in plasma and saliva were determined using GC/MS and GC.The correlation with ketamine(norketamine)concentration in plasma and saliva were artalyzed by a double variable Pearson correlation analysis.Results The correlation coefficients(r)of ketamine (norketamine)concentrations in plasma and saliva were from 0.80 to 0.95 in ketamine i.g.group and i. v.group.Conclusion There is a good relativity between the concentration of ketamine(norketamine)in plasma and in saliva.The ketamine(norketamine)concentration in saliva can be used to estimate the plasma concentration in the forensic identification of ketamine abuse.
