Preparation and property of nano-hydroxyapatite/polyamide66 composites for ilium-grafting in bone defect following decompression
10.3969/j.issn.1673-8225.2009.38.011
- VernacularTitle:纳米羟基磷灰石/聚酰胺66颈前路减压后前方骨缺损仿生髂骨的制备及性能
- Author:
Yinyin ZHOU
;
Tao WANG
;
Jie TAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(38):7455-7458
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: After excision of vertebra and cervical intervertebral disc, repairs of bone defect after reducing pressure mainly have used titanium mesh and ilium for a long time, but the effect is not perfect. OBJECTIVE: To prepare nano-hydroxyapatite/polyamide66 (n-HA/PA66) composites, and to test the representation and biomechanical properties. DESIGN, TIME AND SETTING: A repeated and comparative study was performed at Laboratory of Inorganic Material, College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics from January to December 2008. MATERIALS: Nano-hydroxyapatite crystal was prepared using hydrothermal reaction, and the nano-hydroxyapatite/polyamide66 of bone-grafting specimens was prepared by co-precipitation, cold-pressing and sintering. METHODS: Normal C_5 samples were implanted into different materials and then internal-fixed using screw to test the biomechanics. The grouping was as following: normal cervical vertebra group, n-HA/PA66 ilium-grafting internal fixation group, and ilium-grafting internal fixation group. Physiological motion of cervical vertebra was simulate to human body at neutral, flexion, extension and lateral-flexion positions. MAIN OUTCOM MEASURES:① The phase of the composites was characterized by X-ray diffraction. ② The group of thecomposites was analyzed by infrared spectrum. ③ Scanning electron microscopy was used to analyze the scaffold of bone-grafting specimens. ④ The measurements of biomechanical properties were carried out with normal cervical specimens, bone-grafting specimens and the ilium-grafting specimens. RESULTS: ① X-ray diffraction results revealed that the main diffraction curves of nano-hydroxyapatite and polyamide66 remained in the composites, but n-HA would widen and weaken the β crystals in polyamide66. ② Infrared spectrum results showed that nano-hydroxyapatite and polyamide66 were mainly linked by hydrogen-bonding. ③ Scanning electron microscopy examined the scaffold of bone-grafting and revealed that the composites had tight combination and good interface. ④ The measurements of biomechanical properties indicated that the bone-grafting specimens had better performances in load-strain, load-displacement and stress intensity in comparison with ilium-grafting ones, only a little bit lower than the normal cervical vertebrae. CONCLUSION: The bone-grafting specimens have outstanding biomechanical properties and are an ideal kind of material to instead cervical vertebrae.
