The toxicity of aconitum alkaloids on cardiocytes and the progress of its research using the methods of molecular toxicology
- VernacularTitle:乌头类生物碱对心肌的毒性作用及分子毒理学研究进展
- Author:
Yan LIU
;
Shiwei ZHANG
;
Lan ZHOU
;
Liang LIU
- Publication Type:Journal Article
- Keywords:
forensic toxicology;
aconitum alkaloids;
toxicological mechanism;
cardiomyocytes
- From:
Chinese Journal of Forensic Medicine
2009;24(6):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Aconltium plants are a group of important poisonous plants in the Ranunculaeeae family of Angiosperm subphylum.and one of the earliest recorded poisonous plants in China as well.In their tubers(root)have hypertoxic Aconitium alkaloids,which belong to the group of diesterditerpene alkaloids.It is repeatedly reported in China that aconitine poisoning,and even death from aconitine poisoning,caused by the individual differences in pharmaceutical tolerance of aconitine,taking the wrong medicine or inadequate dosage,or put in the poison by homicide.At present,the research on aconitine is mainly limited to clinical treatment,but lack of research on toxicity mechanism of aeonitine.This paper reviews some progress relating to the toxicological mechanisms of this kind of alkaloid.
