Expression of c-jun in injured tissues and its forensic interest
- VernacularTitle:c-jun在组织损伤中的表达变化及其法医学意义
- Author:
Mei YANG
;
Dawei GUAN
;
Changyan XIONG
;
Zihui CHENG
;
Tianshui YU
- Publication Type:Journal Article
- Keywords:
forensic pathology;
immediately eady gene(IEG);
c-jun;
wound
- From:
Chinese Journal of Forensic Medicine
2009;24(6):401-403
- CountryChina
- Language:Chinese
-
Abstract:
Oncogene c-jun is a member of jun family,the immediately early genes(IEGs),and belongs to one of the nuclear transcription factors of basic leucine zipper(bZIP)family.Combined with many gene promotors,c-jun is involved in the regulation of gene transcription.Its products play important roles in regulating gene expression,cell proliferation,differentiation and apoptosis.The structure,biological funetion,regulation of c-jun and its roles contributing to tissue damage are reviewed in this article,which may provide understanding for severity of tissue injury and wound age estimation in the field of forensic pathology.
