Clinical Study of Lymph Node Metastasis and Optimal Lymphadenectomy for Middle Third Thoracic Esophageal Squamous Cell Carcinoma
10.3969/j.issn.1000-8179.2009.23.002
- VernacularTitle:胸中段食管鳞癌淋巴结转移度及合理清扫范围的临床研究
- Author:
Mingran XIE
;
Peng LIN
;
Xu ZHANG
;
Diexin CHEN
;
Yongbin LIN
;
Tiehua RONG
;
Zhesheng WEN
;
Xiaodong LI
;
Junye WANG
;
Hui YU
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasm;
Lymph node metastasis;
Lymphadenectomy
- From:
Chinese Journal of Clinical Oncology
2009;36(23):1325-1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the status of lymph node metastasis of middle third thoracic esophageal squamous cell carcinoma and its influence on the prognosis and to seek the reasonable range of lymphade-nectomy. Methods: A total of 129 patients who underwent curative esophagectomy with modern two-field lymphadenectomy of middle third thoracic esophageal squamous cell carcinoma were reviewed. Results: The lymph node metastasis rate was 56.6% and the upper mediastinal lymph node metastasis rate was 43.4%. The lymph node metastasis ratio (positive nodes/total dissected nodes, LMR) was 11.3%. Paraesophageal lymph nodes, lymph nodes near the right recurrent nerve, the left gastric and infracadnal lymph nodes were most commonly involved when the tumor was located in the middle thoracic esophagus. Tumor differentiation, the depth of tumor invasion and the length of tumor were influencing factors for lymph node metastasis. The 5-year survival of N_0, N_1 (LMR≤20%) and N_1 (LMR>20%) patients were 50.4%, 31.0% and 6.8%, respective-ly, with a significant difference among the three groups (P=0.000). Conclusion: LMR was one of the key fac-tors affecting the prognosis, of esophageal cancer. Patients with middle third thoracic esophageal carcinoma should be treated with radical surgery with modern two-field lymphadenectomy.
