To study On the functional change of thrombosis and haemostasis system in patients with cerebral infarction
10.3760/cma.j.issn.1673-4130.2009.11.006
- VernacularTitle:脑梗死患者止凝血系统功能改变的研究
- Author:
Yan DOU
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Tissue plasminogen activator;
Type 1 plasminogen activator inhibitor;
Factor Ⅷ
- From:
International Journal of Laboratory Medicine
2009;30(11):1055-1057
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change trend for D-dimer,antithrombin activity (AT:A),tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1 (PAI-1)and yon Willebrand factor (vWF) before and after treatment in patients with cerebral infarction,so as to evaluate the clinical value of the above parameters in therapeutic effect monitoring of cerebral infarction.Methotis SYSMEX CA7000 blood coagulation analyzer was applied to determining plasma D-dimer,t-PA,PAI-1 and AT:A,and ELISA was adopted to measure vWF.Results Compared with those of healthy control group,D-dimer,PAI-1 and vWF were significantly increased (P<0.01),t-PA was significantly decreased (P<0.01),and AT:A had no change (P>0.05) in cerebral infarction group before treatment.In cerebral infarction group,compared with those of pre-treatment,D-dimer,PAI-1 and vWF were significantly decreased (P<0.01),t-PA was significantly increased(P<0.01),and AT:A had no change(P>0.05) after treatment.So was the situation between GCS>8 and GCS≤8group.Conclusion There are obvious changes of fibrinolytic system parameters and vWF level befor and after treatment in patients with cerebral infarction,and the changes are associated with the course of disease.
