Study on dehydroepiandrosteron permeation from Transdermal Therapeutic Systems
- Author:
Tu Minh Cong
- Publication Type:Journal Article
- Keywords:
Transdermal therapeutic systems
- MeSH:
Dehydroepiandrosterone;
Administration, Cutaneous;
Therapeutics
- From:Pharmaceutical Journal
2005;0(11):14-16
- CountryViet Nam
- Language:Vietnamese
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Abstract:
To study in vitro usability of Transdermal Therapeutic Systems (TTS) dehydroepiandrosteron (DHEA) on pig's ear skin. Results showed that: there was correlation about DHEA permeation between human and pig's ear skin. DHEA permeation speed was linear proportional with square root of time and the DHEA content in TTS. DHEA permeation speed via human skin had linear correlation with permeation speed via pig's ear skin with angular co-efficient 0.74; this showed that pig's ear skin can be used for exploratory research on establishing formulation of transdermal drugs. Pig skins are available material and easy to collect with large amount. However, this result also showed that permeation ability of human skin is lower than pig’s ear skin
