Prognostic Factors for Survival of 138 Patients with Stage Ⅳ Gastric Cancer
10.3969/j.issn.1000-8179.2009.23.005
- VernacularTitle:138例Ⅳ期胃癌患者预后因素分析
- Author:
Zhixiang ZHUANG
;
Yufeng LU
;
Liqin SHEN
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Platinum;
Chemotherapy;
Prognosis
- From:
Chinese Journal of Clinical Oncology
2009;36(23):1336-1339
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the prognostic factors of patients with stage Ⅳ gastric cancer. Meth-ods: A total of 138 patients with stage Ⅳ gastric cancer treated with platinum-based chemotherapy were ana-lyzed. Survival rate was estimated by Kaplan-Meier method. The prognostic factors were analyzed by univari-ate (Log rank) and multivariate (Cox model) analysis methods. Results: Univariate analysis and multivariate analysis showed that poor performance status (P=0.001), weight loss (P=0.001), depth of invasion (P=0.000), presence of peritoneal metastasis (P=0.005), more than 1 metastatic site (P=0.029) and elevated total biliru-bin (P=0.018) were independent prognostic factors. According to the outcomes of the Cox model analysis, a formula of the prognostic index was developed. According to the values of PI, 16 patients were categorized as the high-risk group (PI≤9.817), 28 patients were categorized as the moderate-risk group (9.817