Biomechanical study of long bones and vertebrae in rhesus monkeys
10.3969/j.issn.1673-8225.2009.46.005
- VernacularTitle:猕猴长骨及椎骨的力学性能
- Author:
Tianxiu WU
;
Jinmin LIAO
;
Wenbe LI
;
Yan CHEN
;
Lianfang HUANG
;
Ren HUANG
;
Liao CUI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(46):9027-9031
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The mechanical properties of monkeys are the closest to the human body.Monkey is the ideal animal model of osteoporosis research.OBJECTIVE:To explore the biomechanical properties of the long bones and vertebrae in rhesus monkeys.DESIGN.TIME AND SETTING:The mechanics experiment for the study was based on monkeys,which was completed in the South Medical University,Key Laboratory of Medical Biomechanics in Octobor 2006.MATERIALS:Four male macaca mulattas aged 17.5 years on average and three female crab-eating monkeys aged 9 years on average.METHODS:Long bones(femur,tibia,fibula,humerus,radius and ulna)and the third and fourth lumbar vertebrae of three adult crab-eating monkeys and four old macaca mulattes were teken to do four-point bending test,torsion test,indentation test and compression test respectively.MAIN OUTCOME MEASURES:①The results of compression experiments and indentation experiments in monkey vertebrae.②The maximum load and the rigidity factor in left side of long bone of monkeys.③The maximum torque(N·m)in the right side of long bone of monkeys.RESULTS:①In the four-point bending tests,the maximum Ioad of the left ulna,fibula,humerus,femur,tibia and radius in macaca mulattas were(574.16±163.53),(179.98±38.32),(1487.9±965.12),(1928.60±336.23),(1303.23±969.35),(559.92±1.12)N,respectively.While the rigidity factor of the left femur,tibia,fibula,humerus,radius and ulna in macaca mulattas were (53.49±14.22),(28.41±5.86),(114.22±13.24),(142.16±18.56).(101.11±15.46),(69.13±5.54)N/mm,respectively.The maximum load of the left femur,tibia.fibula,humerus,radius and ulna in crab-eating monkeys were(179.93±19.38),(53.82±5.31),(631.61±225.81),(726.07±245.69),(424.52±49.s0),(1 91.97±67.73)N,respectively;however,the rigidity factor of the left femur,tibia,fibula,humerus,radius and ulna in crab-eating monkeys were(21.45±2.63),(16.25±6.66),(68.5±12.22),(76.79±14.01),(41.80±2.79),(64.31±15.89)N/mm,respectively.②In the torsion test,the maximum torque of the right fibula,humerus,femur and tibia in macaca mulattas were(1.55±0.82),(22.26±4.26),(30.93±6.54),(17.49±4.04)N·m,respectively.The maximum torqua of the right fibula,humerus,femur,tibia in crab-eating monkeys were(0.81±0.15),(10.34±2.06),(11.58±0.76),(6.68±1.34)N·m,respectively;③In the compression test,the maximal compression load and the rigidity factor of L4 in macaca mulattas were (2811.21±403.90)N,and(69.47±8.92)N/mm,respectively;the maximal compression load and the rigidity factor of L4 in crab-eating monkeys were(1659.90±339.08)N,and(36.29±6.61)N/mm,respectively.④In the indentation test,the maximal indentation and the maximal anti-pressure of L_3 in macaca mulattas were(521.90±38.94)N,and(699.16±43.46)MPa,respectively;the maximal indentation and the maximal anti-pressure of L_3 in crab-eating monkeys were(614±145.94)N,and (815.92±193.69)MPa,respectively.CONCLUSION:Experimental data derived from the experiments demonstrated that rhesus monkeys as a kind of nonhuman primate animals have an important reference value in the animal studies of osteoporosis.
