Clinical Significance of FGFR1OP and p57 (Kip2) Proteins in Gliomas: An Immunohistochemical Study
10.3969/j.issn.1000-8179.2009.23.015
- VernacularTitle:胶质瘤中FGFR1OP和p57/Kip2蛋白的临床意义
- Author:
Yonggang TAN
;
Wei ZHENG
;
Hao WANG
;
Huawei ZOU
;
Fengping SHAN
- Publication Type:Journal Article
- Keywords:
Glioma;
FGFR1OP;
p57/Kip2
- From:
Chinese Journal of Clinical Oncology
2009;36(23):1367-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of FGFR1OP and p57/Kip2 proteins on the genesis and progression of gliomas and their clinical significance. Methods: The expression of FGFR1OP and p57/Kip2 in 54 glioma specimens was detected by SP immunohistochemical technique. The relationship between the ex-pression levels of those proteins and various clinical pathologic factors was evaluated. Results: The expres-sion of FGFR1OP and p57/Kip2 was found in 66.7% and 44.4% gliomas, respectively. The OD value of FG-FR1OP was 0.131±0.010 in high grade gliomas, and 0.118±0.010 in low grade ones, with a statistical signifi-cance (t=-5.497, P=0.000), showing that higher expression of FGFR1OP was significantly associated with glo-ma cell differentiation. The OD value of p57/Kip2 was 0.156±0.008 in high grade gliomas, and 0.165±0.006 in low grade ones, with a statistical significance (t=0.296, P=0.014), showing that lower p57/Kip2 expression was correlated with high grade gliomas. FGFR1OP was negatively correlated with p57/Kip2 in gliomas (r=-0.732, P<0.01). Conclusion: Increased expression of FGFR1OP and/or decreased expression of p57/Kip2 may play an important role in the genesis and progression of gliomas and may indicate a poor prognosis.
