AEG-1 and cancer
10.3760/cma.j.issn.1673-422X.2011.01.003
- VernacularTitle:星形细胞上调基因-1与肿瘤的关系
- Author:
Jia YE
;
Weilin CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Signal pathway
- From:
Journal of International Oncology
2011;38(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Astrocyte elevated gene (AEG) -1 is cloned as a human immunodeficiency virus (HIV) -1-inducible and tumor necrosis factor-alpha (TNF-α)-inducible transcript in primary human fetal astrocytes (PHFA) by a rapid subtraction hybridization approach. AEG-1 has been reported to be up-regulated in various types of human cancers. Multivariate analyses indicat that AEG-1 correlates with the ability of growth, invasion, metastasis, angiogenesis and chemoresistance of tumors. AEG-1 over-expression activates the PI3K-Akt,nuclear factor kappa B (NF-κB) and Wnt-β-catenin signaling pathways in several crucial aspects of tumorprogression. AEG-1 represents a viable potential target for the therapy of human cancers.
