Association of core binding factor alpha 1 and estrogen receptor alpha gene polymorphism with bone development
10.3969/j.issn.1673-8225.2009.46.035
- VernacularTitle:核心结合因子α_1、雌激素受体α基因多态性与骨发育的相关性
- Author:
Yue ZHANG
;
Lijun WANG
;
Fu REN
;
Huanjiu XI
;
Yingnan FAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(46):9159-9162
- CountryChina
- Language:Chinese
-
Abstract:
Produced by bone cells and stored in the matrix.bone ceil growth factor can contribute to the regulation of bone growth.Gene regulation has its role in bone development.Many factors of this kind have been founded recently.They play their role during the bone formation and absorption processes in the way of autocrine and paracrine.The genes of core binding factor α_1(Cbfα_1)and estrogen receptor α(Erα)have been the recent years'hot factors that are related to the bone development,Gene polymorphism refers to variation on gene level which often occurs in the non-coding domain or the domain bearing no important regulatory function in gene order.This article reviewed the research status of the relation between Cbfα_1 and Erα gene polymorphism with bone development.
