Study of 1H-MRS and DWI in the Temporal Lobe Epilepsy

VernacularTitle:颞叶癫痫~1H-MRS和DWI的变化及其相关性研究
Author: Xiaoshuang XIONG ; Pang DU ; Guangbin CUI ; Qiang LI ; Wei LI ; Wei WANG
Publication Type:Journal Article
Keywords: brain; temporal lobe epilepsy; hippocampal sclerosis; magnetic resonance spectroscopy; diffusion weighted imaging
From: Journal of Practical Radiology 2009;25(12):1693-1697
CountryChina
Language:Chinese
Abstract: Objective To study the value of~1H-magnetic resonance spectroscopy(~1H-MRS) and diffusion weighted imaging(DWI) in evaluating the changes of pathological structures of hippocampal sclerosis.Methods Twelve normal controls and twelve cases with temporal lobe epilepsy were examined by conventional MRI,~1H-MRS and DWI.The NAA/(Cr+Cho) ratios and ADC values in the hippocampus were measured and compared between patients and normal controls.Results The NAA/(Cr+Cho) ratios of hippocampus in patients with hippocampal sclerosis were significant decrease in comparison with controls and the contralateral side,and the ADC values were also significant increase.There was correlation between the NAA/(Cr+Cho) ratios and ADC values in the disordered hippocampus(r=-0.79,P=0.002).Conclusion There is a significant correlation between the NAA/(Cr+Cho) ratios and ADC values in the hippocampal sclerosis.~1H-MRS and DWI capture partially complementary aspects of hippocampal pathology noninvasively in vivo.