Study on serum levels of adiponectin and its associated factors in type 2 diabetes with insulin treatment
10.3969/j.issn.1006-6187.2009.12.008
- VernacularTitle:胰岛素治疗初诊2型糖尿病患者脂联素水平及其相关因素的研究
- Author:
Qian LI
;
Qi ZHUANG
;
Dongmei LI
;
Xiaojun TAO
;
Ying ZHANG
;
Huiqin LI
;
Guoping YIN
;
Jindan WU
;
Jianhua MA
;
Ling ZHOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Insulin;
Adiponectin
- From:Chinese Journal of Diabetes
2009;17(12):905-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of adiponectin on the pathophysiology and treatment of type 2 diabetes. Methods 50 patients with newly diagnosed type 2 diabetes were given insulin intensive therapy.Body mass index(BMI), blood lipids, blood glucose, insulin and adiponectin were measured before and after the insulin treatment.36 healthy persons were selected to match for sex and age with diabetes patients. Results In type 2 diabetes patients, before insulin intensive treatment,the level of adiponcetin was 4.28(2.11-6.38)μg/L and arose to 12.26(8.22-16.00)μg/L after 12.6±2.1 day insulin treatment.In healthy persons, the level of adiponectin was 9.56(7.92-11.61)μg/L.There was significant difference among the three groups.Adiponectin was negatively correlated with BMI and triglyceride and positively correlated with insulin action index (IAI) and high density lipoprotein (HDL). Conclusions Adiponectin plays a major role in the pathophysiology and treatment of newly diagnosed type 2 diabetes.
