Relationship between homocysteine level and peripheral artery disease in patients with newly-diagnosed type 2 diabetes
10.3969/j.issn.1006-6187.2009.12.011
- VernacularTitle:同型半胱氨酸与新诊2型糖尿病下肢血管病变的关系
- Author:
Yumei PEI
;
Hewei ZHANG
;
Jing XU
;
Hui FANG
;
Jinli TIAN
;
Yazhong ZHANG
;
Weiping WU
- Publication Type:Journal Article
- Keywords:
Diadetes mellitus,type 2;
Homocysteine;
Ankle-brachial index;
Ultrasonography,doppler,color
- From:Chinese Journal of Diabetes
2009;17(12):913-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association between homocysteine (Hcy)level and low limb vascular disease(LLVD) in newly-diagnosed type 2 diabetic patients. Methods The study subjects were divided into three groups : control group (NC), newly-diagnosed type 2 diabetes group without peripheral artery disease (T2DM) and peripheral artery disease with newly-diagnosed type 2 diabetes group (T2DM+LLVD).Both Hcy and the ankle-brachial index(ABI) were measured in three groups. Results Compared with NC group, clinical parameters of body mass index,waist-to-hip ratio,systolic blood pressure, total cholesterol(TC),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),and glycated hemoglobin A1C (HbA1c) increased markedly,and the content of high density lipoprotein-cholesterol (HDL-C) was markedly lower in both T2DM and T2DM+LLVD groups.In T2DM+LLVD group the contents of Hcy,LDL-C and HbA1c were markedly higher than in T2DM group,but the content of HDL-C decreased significantly.Hcy was independently associated with the development of peripheral artery disease in newly-diagnosed type 2 diabetic patients by logisitic regression analysis. Conclusions Increased Hcy is an independent risk factor for peripheral artery disease in newly-diagnosed type 2 diabetes.
