Optimization of riboflavin sodium phosphate loading to calcium alginate floating microspheres by response surface methodology
10.3969/j.issn.1671-167X.2009.06.014
- VernacularTitle:运用响应曲面法优化核黄素磷酸钠海藻酸钙胃漂浮微球
- Author:
Anyang ZHANG
;
Tianyuan FAN
- Publication Type:Journal Article
- Keywords:
Gastrointestinal tract;
Delayed-action preparations;
Alginates;
Flavin mononucleotide;
Technology,pharmaceutical
- From:
Journal of Peking University(Health Sciences)
2009;41(6):682-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres. Methods: The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method. Results: The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM). Conclusion: The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick' s diffusion.
