The application of three-dimensional cell culture technology in the field of cancer research
- VernacularTitle:三维细胞培养技术在肿瘤研究领域的应用
- Author:
Yingyu WANG
;
Yin LU
;
Weiwei ZHANG
;
Zhiguang SUN
;
Shizhong ZHENG
;
Lei CHEN
- Publication Type:Journal Article
- Keywords:
three-dimensional cell culture technology;
tumor model;
extracellular matrix;
microenvironment;
biological behavior;
cell resistance;
angiogenesis;
vasculogenic mimicry
- From:
Chinese Pharmacological Bulletin
2009;25(12):1545-1548
- CountryChina
- Language:Chinese
-
Abstract:
Traditional 2D cell culture technology is widely used in cell culture field, but it lacks the formation of 3D matrix scaffold and lacks specific cytokines in vivo.Cells in 3D cell culture system are similar to cells in vivo for gene expression and cell activity. The article focuses on the application of three-dimensional cell culture technology in cancer research, including the construction of tumor microenvironment,tumor biological behavior, tumor angiogenesis, drug resistance and so on and provides a reference for cancer research workers.
