Duplication of animal models for spinal cord injury and its application in experimental therapeutics
- VernacularTitle:脊髓损伤动物模型的复制及其实验治疗学应用
- Author:
Bing GU
;
Zheng ZHANG
;
Huanan LI
;
Wei MENG
;
Riyue YU
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
animal model;
contusion injury model;
compression injury model;
transection injury model;
experimental therapeutics
- From:
Chinese Pharmacological Bulletin
2009;25(12):1559-1562
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of spinal cord injury and repair therapy after nerve injury is currently a hotspot of neuroscience research.Duplicating animal models plays a key role in experimental therapeutics of spinal cord injury.This review systematically describes the progress in animal models for spinal cord injury including contusion, compression, transection, ischemic,distraction and chemical-mediated injury,which have been established at home and abroad.Based upon the aforementioned models,some applications in experimental therapeutics are simultaneously enumerated.All these information provides scientific guidance for the experimental novel drugs′screening.
