The regulatory effect of recombinant human fibroblast growth factor-21 on the expression of liver X receptor α and glucose transporter protein 1 in the type 2 diabetes rats
- VernacularTitle:重组人成纤维细胞生长因子-21对2型糖尿病模型大鼠LXRα及GLUT1 mRNA表达的调节作用
- Author:
Wenping ZOU
;
Yufei ZHANG
;
Huiyan WANG
;
Yan WU
;
Xiaohuan YUAN
;
Yanhui CHU
- Publication Type:Journal Article
- Keywords:
recombinant human fibroblast growth factor-21(rhFGF-21);
type 2 diabetes mellitus (T2DM);
liver X receptor α(LXRα);
glucose transporter protein 1(GLUT 1)
- From:
Chinese Journal of Biochemical Pharmaceutics
2009;30(6):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To examine the regulatory effect of recombinant human fibroblast growth factor-21 on the expression of liver X receptor α and glucose transporter protein 1 in the type 2 diabetes mellitus rats.Methods The rat models of type 2 diabetic mellitus were divided into four groups at random, ic. rhFGF-21 every day, after eight weeks of these treatment, Inspect the fasting blood glucose (FBG), fructosamine(FA), triglyceride(TG), T-cholesterol(TC), high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) of these rats, then detecting the mRNA expression of LXRα and GLUT1 by RT-PCR.Results (1) rhFGF-21 can reduce blood glucose steadily to near normal levels in diabetic rats. (2) The expression of LXRα and GLUT1 level was significantly higher in the rhFGF-21 treatment group than that in the model group. (3) rhFGF-21 megadoses and middle doses decreased FA, TG, TC,and LDL-C and elevated HDL-C.Conclusion rhFGF-21 could regulate the mRNA expression of LXRα and GLUT1 in diabetes rats, increase basal level glucose transport, then reduce blood glucose, improve lipid metabolize dysfunction.
