The clinicam value of serum connective growth tissue factor(CTGF) in the assessment of liver fibrosis
- VernacularTitle:血清结缔组织生长因子在肝纤维化评估中的临床价值
- Author:
Lin YANG
;
Nianyue WANG
;
Dai ZHANG
;
Chengbao YANG
- Publication Type:Journal Article
- Keywords:
connective tissue growth factor;
liver fibrosis;
histopathology;
receiver operating characteristics curve;
chronic hepatitis
- From:
Chinese Journal of Biochemical Pharmaceutics
2009;30(6):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the relationship between connective growth tissue factor(CTGF) in serum and the severity of liver fibrosis,and to determine the clinical value of CTGF in the assessment of liver fibrosis.Methods Serums CTGF were tested utilizing enzyme linked immunosorbent assay(ELISA).The correlation between serum CTGF concentration and fibrosis stage was assessed.Results The diagnostic performance of CTGF was assessed by comparing the area under receiver characteristic curves(AUC) with a panel of fibrosis markers.Correlation coefficient was 0.689(P＜0.001) between the levels of serum CTGF and fibrosis stages and AUC of CTGF was 0.841(95% confidence interval,0.762-0.920) in distinguishing mild fibrosis from significant fibrosis.Conclusion The present data revealed that serum CTGF was significantly correlated with the stage of liver fibrosis,suggesting that serum CTGF was an indicator for the stage of liver fibrosis,and serum CTGF could be used as a valuable marker assessing liver fibrosis.
